Ausgewählte Literatur

  1. Molekulare Mechanismen der Akkumulation von Schädigung der Makromoleküle im Rahmen der Alterung
Annett K, Duggan O, Freeburn R, Hyland P, Pawelec G, Barnett Y (2005). An investigation of DNA mismatch repair capacity under normal culture conditions and under conditions of supra-physiological challenge in human CD4+T cell clones from donors of different ages. Exp Gerontol. 40:976-81
Brown ML, Franco D, Bürkle A, Chang Y (2002). Role of poly(ADP-ribosyl)ation in DNA-PKcs- independent V(D)J recombination. Proc Natl Acad Sci USA 99:4532-7
d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP, Jackson SP (2003). A DNA damage checkpoint response in telomere-initiated senescence. Nature 426:194-8.
Frappart PO, Tong WM, Demuth I, Radovanovic I, Herceg Z, Aguzzi A, Digweed M, Wang ZQ (2005). An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med. 11:538-44.
Merker K, Ullrich O, Schmidt H, Sitte N, Grune T (2003). Stability of the nuclear protein turnover during cellular senescence of human fibroblasts. FASEB J 17:1963-5.
Mielke C, Christensen MO, Barthelmes HU, Boege F (2004). Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells. J Biol Chem. 279:20559-62.
Scheckhuber CQ, Erjavec N, Tinazli A, Hamann A, Nyström T, Osiewacz HD (2006). Reducing mitochondrial fission results in both increased life span and fitness of two fungal ageing models. Nature Cell Biology, in press
Scheubel RJ, Kahrstedt S; Weber H, Holtz J, Friedrich I, Borgermann J, Silber RE, Simm A (2006). Depression of progenitor cell function by advanced glycation endproducts (AGEs): potential relevance for impaired angiogenesis in advanced age and diabetes. Exp Gerontol 41:540-8.
Strassburger M, Bloch W, Sulyok S, Schuller J, Keist AF, Schmidt A, Wenk J, Peters T, Wlaschek M, Lenart J, Krieg T, Hafner M, Kumin A, Werner S, Muller W, Scharffetter-Kochanek K (2005). Heterozygous deficiency of manganese superoxide dismutase results in severe lipid peroxidation and spontaneous apoptosis in murine myocardium in vivo. Free Radic Biol Med. 38:1458-70.
Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A (2006). Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 16:296-300.
Zsurka G, Kraytsberg Y, Kudina T, Kornblum C, Elger CE, Khrapko K, Kunz WS (2005). Recombination of mitochondrial DNA in skeletal muscle of individuals with multiple mitochondrial DNA heteroplasmy. Nat Genet. 37:873-7.

  1. Zellintrinsische Kontrollpunkte und Veränderungen des Zellumfelds in Antwort auf Akkumulation von Schädigung
Chapouton P, Adolf B, Leucht C, Tannhauser B, Ryu S, Driever W, Bally-Cuif L (2006). her5 expression reveals a pool of neural stem cells in the adult zebrafish midbrain. Development 133:4293-4303.
Gellermann GP Appel TR, Tannert A, Radestock A, Hortschansky P, Schroeckh V, Leisner C Lütkepohl T, Shtrasburg S, Röcken C, Pras M, Linke RP, Diekmann S, Fändrich M (2005). Raft lipids as common components of human extracellular amyloid fibrils. Proc. Natl. Acad. Sci. U.S.A., 102, 6297–6302
Hack MA, Saghatelyan A, de Chevigny A, Pfeifer A, Ashery-Padan R, Lledo PM, Gotz M (2005). Neuronal fate determinants of adult olfactory bulb neurogenesis. Nat Neurosci. 8:865-72.
Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT (2006). Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443:421-6.
Oustania, S., Hause, G. and Braun, T. (2004). Pax7 directs postnatal renewal and propagation of myogenic stem cells but not their specification. EMBO J 23, 3430-3439.
Roy Choudhury A, Ju Z, Djojosubroto MW, Schienke A, Lechel A, Schaetzlein S, Jiang H, Stepczynska A, Wang C, Buer J, Lee HW, von Zglinicki T,Ganser A, Schirmacher P, Nakauchi H & Rudolph KL (2006). p21-deletion prolongs lifespan of telomere dysfunctional mice without accelerating cancer formation. Nature Genetics, in press
Sohn D, Essmann F, Schulze-Osthoff K, Jänicke RU (2006). p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. Cancer Res, in press
Wilson A, Murphy MJ, Oskarsson T, Kaloulis K, Bettess MD, Oser GM, Pasche AC, Knabenhans C, Macdonald HR, Trumpp A (2004). c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev. 18:2747-63.

  1. Systembiologische Analyse von Signalnetzwerken und genetischen Determinanten der Alterung
Hertweck M, Gobel C, Baumeister R (2004). C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev Cell 6:577-88.
Kempermann G, Chesler EJ, Lu L, Williams RW, Gage FH (2006) Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A 103:780-785
Kirkwood TB, Boys RJ, Gillespie CS, Proctor CJ, Shanley DP, Wilkinson DJ (2003). Towards an e-biology of ageing: integrating theory and data. Nat Rev Mol Cell Biol 4:243-9.
Klein C, Grudzien M, Appaswamy G, Germeshausen M, Sandrock I, Schäffer A.A., Rathinam C., Boztug K, Schwinzer B, Rezaei B, Bohn G, Carlsson G, Fadeel B, Dahl N, Palmblad J, Henter JI, Zeidler C, Grimbacher B, Welte K (2006). Deficiency of HAX1 causes severe congenital neutropenia (Kostmann disease) Nat Genet, in press
Nebel A, Croucher PJ, Stiegeler R, Nikolaus S, Krawczak M, Schreiber S (2005). No association between microsomal triglyceride transfer protein (MTP) haplotype and longevity in humans. Proc Natl Acad Sci U S A. 102:7906-9.
Scheckhuber CQ, Erjavec N, Tinazli A, Hamann A, Nyström T, Osiewacz HD (2006) Reducing mitochondrial fission results in both increased life span and fitness of two fungal ageing models. Nature Cell Biology, in press
Tolhuis B, de Wit E, Muijrers I, Teunissen H, Talhout W, van Steensel B, van Lohuizen M (2006). Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat Genet. 38:694-9

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